POS1403 RADIOSYNOVECTOMY IN A CLINICAL SETTING: AN UNDEREXPLOITED TOOL AT OUR DISPOSAL

Background: Radiosynovectomy (RS) is a useful for treating inflammatory arthritis that fail conventional treatments. The main isotope used Yttrium-90 on large joints as knees, whereas Erbium-169 and Renium-186 are more common in small medium sized respectively. RS safe procedure since the isotopes cannot escape synovial capsule or be absorbed into circulation. It is, however, lethal against cells within inflamed joint. most rheumatic disease treated with rheumatoid (RA), followed by axial spondyloarthritis (SpA) idiopathic juvenile (JIA). has also been persistent synovitis after joint replacements, pigmented villonodular (PVNS) undifferentiated arthritis. Objectives: To describe experience of tertiary rheumatology center compare patients without clinical response to treatment following 12 months. Methods: Observational retrospective study between May 31st 2013 October 2019. We collected demographic variables, data about patient, affected, utilized, presence Baker’s cyst, systemic received, need additional infiltrations (before after), complications any changes medication up year procedure. All were performed ambulatory radioisotope infiltration was guided ultrasound, 40mg triamcinolone infiltrated after. SPSS v23 statistical analysis; Chi2 qualitative variables Student’s T distribution quantitative variables. Results: evaluated 67 49 total. them refractory treatment. 44 (65.7%) women, median 53.4 years age (IQ 43.4-67.1). duration 12.5 seemed fare better longer patient had (median 13.5 vs 6.5 p<0.001). where 46 (68.6%) 14 (20.9%) wrists 7 (15.2%) elbows. Out 16 (34.8%) belonged RA effective (87,5%). 100% elbows an response, 6 (85.7%) RA. However, even when 9 (64.2%) diagnosis, only 3 (21.4%) effective. Of PVNS, out 8 (75%) no shown Table 1. compared diagnosis. TOTAL EFFECTIVE INEFFECTIVE p (100%) 21 (31.3%) Inflammatory Arthritides (RA + PsA SpA sJIA), (% ) 52 (77.6) 39 (75% 13 (25%) <0.0001 30 (44.7) 22 (73.3 (26.6) <0.001 positive ACPA/FR (70) 15 (71.4 (28.6) Psoriasic (PsA) (9) 4 (66.6) 2 (33.3) 0.42 10 (14.9) (80) (20) 0.45 sJIA 5 (83.3) 1 (16.6) 0.55 PVNS (11.9) (25) (75 Inespecific monoarthritis (4.4) (100) 0 (0) 0.23 OA Calcium Pyrophosphate Deposition (CPPD) (5.9) (50) 0.33 Intra articular corticosteroids needed before RS, differences ineffective joints; however it significantly lower first six months (0% 43% p<0.0001) remained so 19% Only (28%) change (43%) those (p<0.0001). None complication during follow up. Conclusion: Our showed knees they overall good treatment, especially if diagnosis Patients procedures leest less infiltrations. In our study, than (25% 75% have best overall. References: [1]Liepe K. Efficacy radiosynovectomy Rheumatol Int. 2012 Oct; 32(10):3219-24. [2]Ćwikła JB, Żbikowski P, Kwiatkowska B, Buscombe JR, Sudoł-Szopińska I. diseases. J Ultrason. 2014 Sep; 14(58):241-51. Disclosure Interests: declared